Contemporary approach to osteosarcopenia

Introduction. The elderly are at high risk of developing osteosarcopenia, which is characterized by the coexistence osteoporosis and sarcopenia. There many factors that affect interaction between bones muscles: genetics, hormones, nervous system, aging, cardiac rhythm, nutrition. Pathophysiology osteosarcopenia. Risk include: age 50 years over, sex, Caucasian race, genetic predisposition, short stature, malnutrition, physical inactivity, amenorrhea, late menarche, early menopause, estrogen androgen deficiency, alcohol consumption, cigarette smoking, calcium deficiency in diet, use some drugs. Complications osteosarcopenia include frequent bone fractures, disability, mortality population. Diagnostics. gold standard magnetic resonance imaging computed tomography to assess muscle tissue. Bioelectric impedance analyzes composition body, based on speed electricity moves through tissues. Drug treatment Modern includes application bisphosphonates, selective estrogen-receptor modulators, monoclonal antibodies, hormonal therapy, estrogens, supplementation with preparations vitamin D. Prevention. Lifestyle changes non-pharmacological measures most important for healthy muscles. Physical activity, nutrition rich D, smoking consumption crucial importance people all ages, especially elderly. therapy should be reevaluated least annually, quality life assessed.